My research at CEM focuses on the development of functional liver substitutes using donor livers
that were rejected for transplantation. We aim to repurpose such livers through decellularizing them
and subsequently repopulating them with primary hepatocytes or human induced pluripotent stem cells.
In addition, I am interested in identifying the extracellular matrix factors that play role in liver
function and regeneration through studying rat and human livers at different ages and disease conditions.
Widener UniversityPhiladelphia, PA
Assistant Professor August 2021 – present
CENTER FOR ENGINEERING IN MEDICINE- MASSACHUSETTS GENERAL HOSPITAL - HARVARD MEDICAL SCHOOL Boston, MA
Postdoctoral Research Fellow September 2018 – July 2021
Whole human liver decellularization and recellularization for repurposing livers clinically not accepted for transplantation.
Recellularizing decellularized rat livers with iPSCs for developing in vitro and in vivo functional liver substitutes.
Developing novel wound closure remedies for chronic wound healing.
University of Notre DameNotre Dame, IN
Doctoral Resarcher January 2013 - May 2018
Designed and developed the first hiPSC-derived, in vitro aged myocardial tissue models for modeling age-related cardiovascular diseases using tissue engineering and stem cell culture techniques.
Involved in design and development of myocardium-on-chip model with integrated flow using hiPSC-derived cardiomyocytes and endothelial cells.
Developed HIF-1a knock down hiPSC-derived endothelial cells using shRNA and siRNA targeting to investigate endothelial cell-mediated cardio-protection under cardiac reperfusion injury conditions.
HARVARD UNIVERSITYBoston, MA
Visiting Researcher, Stem Cell and Regenerative Biology June 2014 – February 2015
Developed and characterized HIF-1a knockout hiPSCs using CRISPR/Cas9 technology.
Implemented stem cell culture and differentiation techniques to develop human-origin endothelial cells and cardiomyocytes.
MIDDLE EAST TECHNICAL UNIVERSITYAnkara, Turkey
Graduate Researcher, Biotechnology February 2011 – January 2013
Designed and developed a two-layered, collagen-based tissue engineered cornea model using phase separation and electrospinning techniques and characterized its structure and functionality.
Tissue Engineering and Regenerative Medicine
Developing 3D in vitro tissue models and whole organ substitutes.
Aging Research – in vitro Aged Tissue Models to Study Age-related Diseases
Modeling Age-related Cardiovascular and Metabolic Diseases in vitro and in vivo.
Stem Cell Research
Developing iPSC-based therapies using tissue and animal models.
BIOMEMS - Organ-on-chip Technology
Cardiovascular and metabolic disease models on-chip for clinical applications.
University of Notre DameNotre Dame, IN
Bioengineering Graduate Program May 2018
Dissertation topic: hiPSC-based, human-origin, aged in vitro cardiac disease models.
Advisor: Dr. Pinar Zorlutuna.
Middle East Technical University (METU)Ankara, Turkey
M.Sc. (Biotechnology Graduate Program) January 2013
Seminar Series Organization Center for Engineering in Medicine
Involved in the organization of Spring 2019 Seminar Series at Center for Medicine in
Engineering, Massachusetts General Hospital – Harvard Medical School. Contacted researchers that excel in various disciplines of biomedical engineering and helped arranging 7 seminar talks for Spring 2019.
High School Student Mentorship University of Notre Dame
Trained a high school junior on basic principles of tissue engineering for introducing her to science and research and help her to have her own project for two years.
Undergraduate Student Mentorship University of Notre Dame
Trained 7 undergraduate students with various backgrounds on basic principles of tissue engineering for introducing them to science and research in graduate level and mentoring them on their own projects.
Workshop Organization University of Notre Dame
Organized and lead the workshops that includes an oral presentation and hands-on experience of cell and tissue culture and basic tissue engineering concepts for my research group in Expending Your Horizons Conference in 2016, 2017, and 2018.